For the second season running, Tottenham have lost both first-choice centre-backs at the start of November, contributing to Ange Postecoglou's selection concerns for Thursday's Europa League game against Galatasaray.
Micky van de Ven suffered another hamstring strain against Manchester City last week, although not as serious as the injury which sidelined him for two months at the same stage of last season, to rule the Dutchman out until after the international break.