
On October 2, Katalin Karikó and Drew Weissman jointly received the Nobel Prize in Medicine or Physiology 2023 for their discoveries of how mRNA interacts with the immune system, which ultimately laid the foundation for vaccines against Covid-19. While you might remember mRNA technology as the basis for the rapid development and deployment of Covid-19 vaccines, this technology has been in development for decades. The pair, a biochemist and physician, respectively, began collaborating as colleagues at the University of Pennsylvania in the early 1990s, examining how different types of RNA interact with the immune system.