The 2023 Nobel Prize for Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for developing the mRNA vaccine technology that became the foundation for history’s fastest vaccine development programme during the COVID-19 pandemic. The prizes acknowledge work that has created benefits “for all mankind”, but if we had to be stricter about holding scientific accomplishments up to this standard, the subset of mRNA vaccines used during the COVID-19 pandemic may not meet it. Yet, Dr. Karikó and Dr. Weissman, and others, deserved to win the prize for their scientific accomplishments. Instead, their triumph tells us something important about the world in which science happens and what “for all mankind” should really mean.
Dr. Kariko and Dr. Weissman began working together on the mRNA platform at the University of Pennsylvania in the late 1990s. The University licensed its patents to mRNA RiboTherapeutics, which sublicensed them to CellScript, which sublicensed them to Moderna and BioNTech for $75 million each. Dr. Karikó joined BioNTech as senior vice-president in 2013, and the company enlisted Pfizer to develop its mRNA vaccine for COVID-19 in 2020.
