In December 2000, the Queen and Prince Philip visited Newcastle to officially open the Centre for Life science centre.
More than two decades on and following the Queen's death, Linda Conlon - chief executive at the centre - told ChronicleLive how the monarch's visit had made a fantastic difference. She also spoke about how moving it was to see the Queen "light up" when meeting local children.
Linda, who was made an MBE in 2016, reminisced about the Queen's visit - and how a striking image of the Queen looking down a microscope was captioned by the media as: "The Queen loves Life."