Darvel's capitulation against Falkirk on Monday evening killed off any idea that the sixth-tier side could reach the Scottish Cup semi-finals - though one non-top flight side will have their day at Hampden after the quarter-final draw.
Ayr United were nearly on the wrong end of a shock themselves, levelling against League Two Elgin City in the last minute. Their class showed in extra-time however, and they ran out 4-1 winners to book a spot in the last eight. The draw prior to the Bairns' meeting with the cup shock kings of the fourth round meant they knew a win would pit them against The Honest Men, led by former Falkirk favourite Lee Bullen.
Celtic being handed a trip to Tynecastle means one of the three favourites to lift the trophy will be eliminated. Rangers are expected to take care of Raith Rovers at Ibrox, while Kilmarnock have been warned about Inverness CT's capabilities after they grabbed their second chance following reinstatement with a convincing win over Livingston.