The best guns in the Resident Evil 4 Remake come in many forms: Shotguns that can blast villagers in half, powerful submachine guns that shoot through multiple targets, and a secret automatic rifle that melts just about anything you unload it into. While it's hard to beat classics like the Red9 handgun or the Broken Butterfly magnum, there are plenty of new weapons to try out, too.
Though not a gun, my personal favorite weapon in Resident Evil 4 Remake might be the Primal Knife—a blade you can upgrade to be indestructible for endless neck stabbing and killing pesky parasites before they burst. If you're looking for powerful guns, this secret weapons guide might help. Otherwise, here are the best guns—and knife—in the Resident Evil 4 Remake.
