Bristol and Cornwall have declared major incidents as Storm Eunice heads for the city.
Both Severn crossings will likely close due to Storm Eunice, Avon and Somerset Police said.
Schools in Bristol have been advised to close as Brits prepare for 'danger to life' winds of up to 100mph.
It comes after the Met Office issued a red weather warning for part of Wales and England on Friday.
In preparation for Friday, Bristol City Council and Cornwall Council have declared a major incident.
Bristol City Council tweeted: "A major incident has been declared in the Bristol area ahead of #stormeunice and the public have been advised to avoid travelling on Friday morning wherever possible.
"Due to this we have advised Bristol schools to close tomorrow - please wait for your school to issue updates."
Avon and Somerset Police has warned the two bridges connecting England and Wales - the M4 Prince of Wales Bridge and the M48 Severn Bridge - may close due to high winds on Friday.
Cornwall Councill has also declared a major incident over Storm Eunice.
A spokesman for the council said: "The Council and its partners are working together to prepare and are ready to respond to reports of damage.
"Storm Eunice is set to bring damaging winds across the whole of the peninsula, with the worst affected areas, including the whole of the North Cornwall coast seeing the red warning issued for between 7am and noon.
"The whole of the peninsula is also under an amber weather warning for strong winds and disruption from 5am to 9pm.
"Residents are being advised not to travel unless absolutely necessary, and to stay away from exposed coastal areas."
Non-essential roadworks in the region have been put on hold.
A council spokesman added: "Schools are being provided with the latest forecasts, and decisions on whether to open will be made on an individual basis."
In Ceredigion, Wales, all council services will be suspended on Friday, which includes leisure centres and swimming pools, museums, libraries and waste collection services.
All schools in the county will deliver remote learning.
The London Eye will also temporarily shut on Friday due to the weather.
A statement on its Twitter account said: "Due to severe weather disruption the London Eye and River Cruise has taken the difficult decision to close tomorrow (Fri 18 Feb).
"The safety of our guests is our number one priority and we apologise for any inconvenience caused."
Motorists in Devon and Cornwall are being urged to stay at home because of Storm Eunice.
An amber weather warning for wind will also come into force across much of the UK on Friday, alongside yellow weather warnings for snow and wind.
Superintendent Adrian Leisk, strategic lead for roads policing in Devon and Cornwall, said: "Red weather warnings are extremely rare so I would urge everyone to take extreme caution under the circumstances.
"Please do not travel in your vehicle unless your journey is absolutely necessary. If you can stay or work at home, then please do - particularly in the morning when the red weather warning is in place. If you absolutely have to make a journey, leave early and give plenty of time to allow for any disruption.
"Drive slowly to give yourself maximum time to react, turn your lights on to make sure you are visible and, if possible, avoid travelling on roads located near trees or on the coast.
"At present, this weather warning is only in place for one day so please don't put yourself and others in risk for the sake of a journey which doesn't need to be made."
Get all the latest news sent to your inbox. Sign up for the free Mirror newsletter
Boris Johnson has confirmed the army is "on standby" to deal with the effects of the storm.
On a visit to RAF Waddington in Lincolnshire, the Prime Minister was asked if he would deploy the army to combat the red weather warnings put in place by the Met Office and whether financial help would be available for those affected.
Boris Johnson said in response: "So for those who have already been affected by Storm Dudley, we are offering all the support that we can.
"My sympathies to those who are still without power - we are working with the power companies, the local authorities to get their juice restored as fast as possible."
