West Ham travel to St Mary's for the chance to reach the quarter-finals of the FA Cup for the first time in six seasons when they face Southampton.
The Irons are 11/5 with Betfred while Southampton are the slight favourites at 13/10 and a draw is 5/2.
The Saints have been impressive at home lately, picking up four wins in their last five matches and are currently on a six-match unbeaten run in all competitions too.