Ruben Selles vowed Southampton will "fight until the very last point" after his side slipped closer to Premier League relegation following a damaging 1-0 defeat to Bournemouth. Marcus Tavernier's second-half winner at St Mary's left the the division's bottom club six points from safety with five games to go.
The Saints head to St James' Park on Sunday to face Eddie Howe's high-flying Newcastle, having already lost three times to United this season. The Magpies won the return Premier League fixture 4-1 at St Mary's back in November, before winning both legs of their Carabao Cup semi-final earlier this year.
And they could even be without talisman midfielder James Ward-Prowse after he came off in the second half on Thursday night with a sore throat. A painful defeat to their south-coast rivals inflicted a club-record 11th home league loss of the season on Southampton, with lingering hopes of survival fading fast. Beleaguered Saints thought they had snatched a dramatic draw but Che Adams' 89th-minute effort was disallowed for offside following VAR intervention.