A stoppage-time winner from Ryan Sessegnon revitalised Fulham's European qualification prospects and denied Southampton the chance to move past the record-low Premier League points total set by Derby.
Jack Stephens' 14th-minute opener had already-relegated Saints on course for a first home league victory since November, but Emile Smith Rowe levelled for Fulham after 72 minutes to set up a nervy finale at St Mary's.
