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Andrew Bubak, Associate Professor of Neurology, University of Colorado Anschutz

Shingles can cause severe chronic pain – new research on how exosomes alter neurons offers pathways to treatment

Varicella zoster virus, also known as human herpesvirus 3, causes chickenpox and shingles. BSIP/Universal Images Group via Getty Images

Shingles can cause pain that is notoriously difficult to manage and can last for months to years for some people. The pain can be so severe that it causes a significant decline in quality of life and can be accompanied by suicidal thoughts and emotional distress.

If the pain lasts longer than three months, doctors call the condition post-herpetic neuralgia. Because the underlying mechanisms driving this persistent pain are unknown, treatment options are centered on relieving symptoms but largely fall short. Less than 50% of patients achieve meaningful pain relief.

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