The GTA 6 extended look live reveal made a point of emphasizing how dual protagonists Jason and Lucia can engage with NPCs in a range of ways, both verbally and physically. Rockstar North co-studio head Rob Nelson says NPC interactions have evolved considerably, with GTA 6 standing on the shoulders of Red Dead Redemption 2 in many ways.
Speaking with IGN, Nelson says "we pushed interaction with NPCs as far as we could for Red Dead Redemption 2" but GTA 6s "taking it much further."