Mark Nawaqanitawase will make his State of Origin debut for NSW after Casey McLean was ruled out of game two with a leg injury suffered at training.
Uncapped Dolphins centre Jack Bostock replaces Nawaqanitawase on the bench as the Blues fight to clinch the three-match series with a win on Wednesday night.
McLean strained his right quadriceps muscle in the warm-up at Central Coast Stadium on Saturday as the Blues held their last field session before flying to Melbourne.
After debuting in the game-one win, the Penrith centre had been on track to overcome a minor ankle issue and replace the injured Stephen Crichton for his first Origin start.
Instead, McLean hands left-centre duties to Manly's Tolu Koula, who shifts in from the wing.
