"Congrats to the owners of a brand new $6k paperweight," Riot Games taunts on X. A whole bunch of nefarious hardware tinkerers seem to now be on the wrong end of the company's Vanguard anti-cheat, as it seems Riot has gone beyond kernel-level and confounded even cheaters' attempts to bypass the anti-cheat by using a physical piece of hardware that directly accesses system memory to get to game data.
As anti-cheats have gotten more advanced, so have cheats, thus the perpetual arms race between game devs and cheaters. Usually, this involves going deeper and deeper into the system.