Three days of rest, recovery and practice yielded a rust-filled horrendous first period from which the Islanders could not recover.
The Bruins beat the Islanders for the first time in six tries, 4-1, on Thursday night as the Islanders opened a three-game road trip, including another game in Boston on Friday night.
The Islanders (27-12-4), who remained two points behind the first-place Capitals in the East Division, had not played since concluding a 5-1-0 homestand with a 3-2 overtime win over the Rangers on Sunday night at Nassau Coliseum.