Before I get started, consider this a big spoiler warning for Resident Evil Requiem because I'm about to talk all about the ending and what it means for the series' future. Certain things happen that could potentially change Resi forever so, if you've not rolled credits or know what happened, stop reading now.
Requiem ends with the final discovery of what Elpis is, the MacGuffin you spend much of the game chasing. At the finale it's revealed to be an antivirus for Umbrella founder Oswell Spencer's line of Progenitor bioweapons; something he created after a deathbed realization that being the eugenist creator of an engineered virus responsible for millions of deaths was probably a bad thing. It means anything derived from the original virus – the T, G, C, Uroboros virus, and so on – is potentially just… gone. Removed from the Resident Evil universe by this new cure-all that saved Leon and removed Zeno's powers.
If it plays out how the ending suggests, it's probably the biggest and most exciting thing the series has done since that first zombie turned his head in the mansion. Obviously, getting rid of all the monsters in a monster game might not sound like the best idea, but hear me out.
