Reason Party leader Fiona Patten has conceded defeat in her bid to retain a seat in Victoria's upper house in the state's election.
Ms Patten was seeking re-election in the Northern Metropolitan Region but has not gained enough votes to retain her seat.
In a statement, Ms Patten described the result as "disappointing" but said it was a privilege to serve two terms in parliament.
"I would like to thank the voters for giving me an extraordinary eight years as a lawmaker. I tried every day to make things a little better and fairer," she said.
"I was honoured to be welcomed to so many parts of so many communities."
Ms Patten listed advocating for assisted dying legislation, harm minimisation reforms in drug law, and spent convictions reform among her achievements while in office.
She was also instrumental in the decriminalisation of sex work and the implementation of safe access zones to abortion clinics.
"I think I've put up more private members' bills than any other independent in this parliament, but more importantly, many of them have been successful," she told the ABC.
She said her biggest regret was not getting the legalisation of cannabis through parliament, and not getting support for a bill to outlaw preference harvesting.
Ms Patten said she hoped that after she leaves office, the parliament would implement reforms she was pushing for, including ending the daily recital of the lord's prayer, establishing a portfolio for loneliness and capping electoral spending.
Adem Somyurek is on track to win a seat in the upper house for the Democratic Labour Party after his expulsion from the Labor party.
Mr Somyurek was sacked from Labor's front bench in 2020 over branch stacking allegations and resigned from parliament in October, before announcing he was switching to the DLP.
Ms Patten said Mr Somyurek and herself had very different priorities.
"If it wasn't so disappointing, I'd be laughing," she said.
"You couldn't think of two people at the other end of the spectrum, where I have tried to use every single day in the parliament to affect change, and Mr Somyurek, who has not."
Ms Patten registered the Australian Sex Party in 2009, which later rebranded as the Reason Party.
In 2014, she became the first sex worker ever to be elected to an Australian parliament, which she later wrote a book about called Sex, Drugs and the Electoral Roll.
Ms Patten revealed in September she had been diagnosed with cancer and underwent surgery to remove a kidney.
