Senate rejection of Cabinet nominees is a rare event in American political history. The only instance of a new president's nominee being rejected by a Senate vote happened in 1989 when George H.W. Bush nominated John Tower for secretary of defense. Tower's nomination was derailed by reports of excessive drinking and inappropriate behavior, leading to his rejection.
Fast forward to the present day, where the nomination of Florida Rep. Matt Gaetz as attorney general by President Donald Trump has raised eyebrows due to past allegations of sex trafficking. Gaetz has denied any wrongdoing, but the FBI files related to the investigation may surface during his confirmation hearing.