Quote of the day by Stephen Hawking , “What I have learned from life is to make the most of what you have got,” focuses on how people respond to circumstances they cannot change. The message is about using available skills, time, knowledge and opportunities instead of spending all of one’s energy on limitations. Hawking’s life gives context to this idea. He was diagnosed with amyotrophic lateral sclerosis, or ALS, when he was 21. The disease affected his movement and speech, but he continued his work in physics and used his knowledge to study the universe and explain scientific ideas to the public.