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LiveScience
LiveScience
Emily Cooke

POLG diseases: Rare genetic conditions that starve cells of energy and afflicted the late Prince of Luxembourg

Disease Luxembourg Frederik
A high-resolution microscope image of two mitochondria side-by-side. The mitochondria are pink, purple and red, against a green background. .

Disease name: Polymerase gamma-related diseases, called POLG-related diseases for short

Affected populations: POLG-related diseases are a group of rare, incurable conditions caused by inherited gene mutations. These disease-causing mutations are carried by up to 2% of people of Northern European descent. However, not everyone who carries the mutations ultimately develops a POLG-related disorder.

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