Sajid Javid has announced people over 75, the immunosuppressed and those living in care homes will be offered a Covid-19 booster this spring.
The Health Secretary confirmed the top-up jab would help those at the highest risk of serious coronavirus maintain a high level of protection against the virus.
Full details of the rollout will be set out shortly, but the NHS in England will make the extra dose available to at-risk groups from around six months after their last jab.
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Mr Javid said he accepted advice from the independent Joint Committee on Vaccination and Immunisation (JCVI) and urged people who qualify to get the extra jab as soon as it is offered.
He added: "Thanks to our Covid-19 vaccination rollout, we are already the freest country in Europe.
"It has saved countless lives, reduced pressure on the NHS and is allowing us to learn to live with the virus.
"All four parts of the UK intend to follow the JCVI's advice.
"We know immunity to Covid-19 begins to wane over time.
"That's why we're offering a spring booster to those people at higher risk of serious Covid-19 to make sure they maintain a high level of protection. It's important that everyone gets their top-up jabs as soon as they're eligible.
"The JCVI will keep under review whether the booster programme should be extended to further at-risk groups."
According to the UK Health Security Agency (UKHSA), most of the UK's oldest adults received their last vaccine in September or October last year.
The vaccines used in the spring programme will be the 50mcg Moderna vaccine or 30mcg Pfizer/BioNTech vaccine for adults aged 18 and over.
For anyone eligible aged 12 to 18, a 30 mcg Pfizer/BioNTech dose is being offered,
Professor Wei Shen Lim, chair of Covid-19 vaccination on the JCVI, said: "Last year's booster vaccination programme has so far provided excellent protection against severe Covid-19.
"To maintain high levels of protection for the most vulnerable individuals in the population, an extra spring dose of vaccine is advised ahead of an expected autumn booster programme later this year.
"The JCVI will continue its rolling review of the vaccination programme and the epidemiological situation, particularly in relation to the timing and value of doses for less vulnerable older adults and those in clinical risk groups ahead of autumn 2022."
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