Munster skipper Peter O'Mahony makes his seasonal debut as Reds boss Graham Rowntree makes eight changes for the clash with the Dragons at Rodney Parade on Sunday.
O'Mahony, who was superb in Ireland's tour series triumph in New Zealand, is one of a number of Test players to get their new campaigns up and running for the provinces this weekend.
Keith Earls, Simon Zebo and Mike Haley make up Munster's back three, Dan Goggin comes in at inside centre and Craig Casey gets the nod at scrum-half as they look to bounce back after the opening loss at Cardiff Blues.
