Nurses will stage two more strikes next month as a row with the Government over pay shows no clear sign of reaching a resolution.
In an escalation of industrial action, the Royal College of Nursing (RCN) said nurses will strike on February 6 and 7, with more NHS trusts taking part than during two days of strikes in December.
Nurses at 55 NHS trusts in England - including many across Merseyside - are already scheduled to walk out on Wednesday and Thursday this week, but the February action will grow bigger and cover 73 trusts.
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Some 12 health boards and organisations in Wales will also take part in the two consecutive days of strikes. In December, thousands of nurses at trusts across England and Wales took part in two strike days.
RCN chief executive Pat Cullen said of the latest strike announcement: "It is with a heavy heart that nursing staff are striking this week and again in three weeks. Rather than negotiate, (Prime Minister) Rishi Sunak has chosen strike action again.
"We are doing this in a desperate bid to get him and ministers to rescue the NHS. The only credible solution is to address the tens of thousands of unfilled jobs - patient care is suffering like never before. My olive branch to Government - asking them to meet me halfway and begin negotiations - is still there. They should grab it."
The RCN has been calling for a pay rise at 5% above inflation, though it has said it will accept a lower offer.
Inflation was running at 7.5% when it submitted the 5% figure to the independent pay review body in March.
During the strike action, the health service will most likely run a bank holiday-style service in many areas.
For the strikes this week, the RCN has agreed to still staff chemotherapy, emergency cancer services, dialysis, critical care units, neonatal and paediatric intensive care.
Some areas of mental health and learning disability and autism services are also exempt, while trusts will be told they can request staffing for specific clinical needs. When it comes to adult A&E and urgent care, nurses will work Christmas Day-style rotas.
Last Wednesday, Health Secretary Steve Barclay said he does not "think it is right" to "retrospectively" go back to April when it comes to reviewing the current pay award for NHS staff.
It came after reports he is considering backdating any 2023/24 pay rise, due to be finalised in the spring, to this month in order to boost the current year's settlement offer.
Asked on BBC Radio 4's Today programme if he is considering "reopening" the current year's negotiations, Mr Barclay said he has listened to union views on this year's pay award.
He said: "I don't think it is right to go all the way back to April and retrospectively look at April when we're already under way in terms of this year's pay review body. But, of course, the unions made representations about that and what the Prime Minister said at the weekend is nothing is off the table."
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