CSIR-Centre for Cellular & Molecular Biology (CCMB) scientists in collaboration with CSIR-National Chemical Laboratory (NCL) announced on Thursday that they have made progress towards developing a non-toxic bio-drug derived from turmeric through a ‘gene silencing approach’ to treat cancer.
Promising tool
‘RNA interference (RNAi)’ is a gene silencing approach and a promising tool for targeted and focused therapy for chronic diseases like cancer. The lack of safe and effective delivery methods for RNAi molecules is one of the key challenges against using RNAi-based therapy in biological systems.
CCMB’s Dr. Lekha Dinesh Kumar and her group in collaboration with NCL’s polymer science and engineering division have developed nano-curcumin structures (derived from turmeric) to encapsulate the RNAi and other molecules that aid in targeting specific tissues.
The proposed bio-drug is bio-compatible with a higher uptake efficiency, and shows effective site-specific delivery with regression of tumors in two different mouse models of colon and breast cancer. “The use of curcumin, a well-known nutraceutical with high anti-cancer and anti-inflammatory properties with RNAi, showed tumor retardation with six months survival in aggressive models of colon and breast cancer,” says Dr. Kumar.
Cancer is one of the leading causes of death worldwide and the quest to find plausible therapeutic interventions to replace non-specific chemo drugs has been leading to the development of novel strategies to combat cancer. This work has been published in the journal ‘Nanoscale’.
In another study with the School of Nanosciences, Central University, Gujarat and Centre for Advanced Materials and Industrial Chemistry, RMIT Australia, they designed an eco-friendly and pH-responsive dietary fibre inulin-based nanodevice to target colon cancer.
This device suggests the possibility of substituting synthetic substances with natural compounds in bio-drug formulations for better bio-degradability, tissue accumulation, and lesser toxicity.
The results from this work have been published in the journal ‘Nanomedicine’, said an official release.
“We have demonstrated that RNAi combined with appropriate targeting agents and encapsulations made of natural biomaterials have high translational capacity in mice models of cancer. This group of bio-drugs can revolutionize cancer therapeutics. But, it should be assessed in other cancer model systems to bring out the utility of these therapeutics in the clinical trials,” she added.
