Small and medium-sized firms in Northumberland, Tyne and Wear and County Durham could benefit from part of a £40m investment pot over the next two years.
The North East Fund says it wants to invest in at least 150 more companies and is urging businesses to discuss working capital requirements and growth plans with its team.
It follows milestones reached including more than £220m raised for more than 350 regional businesses, creating 1,500 jobs, in the first four years since the fund was launched.