Napoli host Rangers at the Stadio Diego Armando Maradona looking to defend top spot in Group A.
A battle with Liverpool Could go down to the wire, with a trip to Anfield during the final gameweek, although victory here, to complete the double after winning 3-0 in Glasgow, would ensure Luciano Spalletti’s side have significant control given the 4-1 win over the Reds in the home fixture between the sides.
Rangers are playing to salvage some respect after a heavy 7-1 defeat to Jurgen Klopp’s side last time out.
Ajax can still be mathematically caught for a place in the Europa League, too, although the 4-0 loss in Amsterdam makes the head-to-head record tough to overcome, meaning a result here is vital.
Here’s everything you need to know.
What time is Napoli vs Rangers?
The match will kick off at 8pm BST on Wednesday 26 October.
How can I watch it?
The game will be shown live on BT Sport 4, with coverage starting at 7:15pm and you can stream the show via the BT Sport app too.
Confirmed line-ups
Napoli XI: Meret, Di Lorenzo, Ostigard, Minjae, Mario Rui, Ndombele, Lobotka, Elmas, Politano, Simeone, Raspadori
Rangers XI: McGregor; Tavernier, King, Davies, Ridvan; Sands, Lundstram; Tillman, Wright, Kent; Morelos
Odds
Napoli: 1/5
Draw: 11/2
Rangers: 12/1
Prediction
Rangers will do well to lose by two here given the form of both teams, with Napoli rampant against Ajax last time out and handing Liverpool a heavy loss here too. The hosts are flying and competition is fierce, which should mean standards remain high for the Serie A leaders to coast to a big win. 3-0.