- Mustang Bio Inc (NASDAQ:MBIO) announced updated interim data from the ongoing Phase 1/2 trial of MB-106, a CD20-targeted, autologous CAR T cell therapy for relapsed or refractory B-cell non-Hodgkin lymphomas (B-NHLs) and chronic lymphocytic leukemia (CLL).
- MB-106 is being developed in a collaboration between Mustang and Fred Hutchinson Cancer Center.
- The data demonstrated high efficacy and a favorable safety profile in all patients (n=25).
- Five dose levels were used during the study, and complete responses were observed at all dose levels.
- Durable responses were observed in a wide range of hematologic malignancies.
- An overall response rate (ORR) of 96% and a complete response (CR) rate of 72% was observed in all patients across all dose levels. Additionally, two patients had been previously treated with CD19-directed CAR T therapy and subsequently relapsed. Both responded to treatment.
- CAR T expansion was observed across all dose levels.
- A favorable safety profile was observed in all 25 patients. No patients experienced severe cytokine release syndrome or immune effector cell‐associated neurotoxicity syndrome.
- Price Action: MBIO shares are down 2.60% at $0.79 during the market session on the last check Monday.
