Mishal Husain has been responsible for some of BBC Radio 4’s most memorable on-air clashes with politicians.
The presenter is set to depart the Today programme after 11 years on air.
Husain, 51, has worked at the broadcaster for more than 27 years.
In a statement, she said: “I will always be grateful for the opportunities the BBC gave me, and wish the organisation and everyone who is part of it the very best.”
Husain previously hinted at her exit when she told The Sunday Times in June that she was “thinking about what is beyond Today” and was “wondering what the next act of my career might look like”.