Lionel Messi could not help Argentina extend its unbeaten streak since its World Cup title.
Uruguay beat Argentina 2-0 at La Bombonera Stadium in Buenos Aires on Thursday in a World Cup qualifying match, its biggest victory so far under new coach Marcelo Bielsa.
Argentina hadn't lost a competitive match since its group-stage opener against Saudi Arabia during last year's World Cup in Qatar. It hadn't lost at home since falling 1-0 to Paraguay in 2016, also during World Cup qualifying.