Tottenham, and especially Antonio Conte, won't see the 1-0 first leg deficit as an insurmountable one, but they were disappointing in going down to a defeat at the San Siro.
Brahim Diaz, the former Manchester City youngster, bundled home the ball in just the seventh minute for what turned out to be the only goal of the game, with the Spaniard reacting after Fraser Forster had brilliantly kept out his first effort.
Spurs struggled to create much throughout the night, and could have ended up losing by more goals but for missed headed chances from Charles De Ketelaere and Malick Thiaw.