Max Malins returns from a foot injury to start at full-back while Billy Vunipola makes his 150th appearance for Saracens when they take on Worcester on Saturday.
England’s Malins pulled out of last week’s win over Exeter but is straight back into the side at full-back as one of three changes.
As he was against Exeter, Maro Itoje is given a rest ahead of the run-in which sees Sarries qualified for the Premiership play-offs and in the latter stages of the European Challenge Cup.
Vunipola brings up a significant milestone for the club.
“It’s a massive honour for me to bring up 150,” he said. "We’ve had some incredible moments together as a group and we’re as motivated as ever to create even more in the coming years.”
On Friday, Harlequins can effectively seal their play-off place with victory over Northampton, whose own hopes of making the top four would be dealt a severe blow by that result.
Quins have made three changes, two of them at prop, and have promised to stick to their attacking brand of rugby.
“One of the wrangles when you play a team like Saints, or us, that play an attacking brand of rugby is whether you can stifle their ability to create line breaks and score tries. If you can, it goes a long way towards getting a result.
“Although that doesn’t mean we will be entirely defensively focused this week, because we want to make sure we carry the ball in the right places and put them under pressure and score some tries as well.”
