They said it couldn't happen. They said it was impossible. They said Nintendo would never put one of its games on PC. And they were right; Nintendo has not.
But who cares? Because someone else has—the legends known as The Harbour Masters have managed to natively port Mario Kart 64 to PC, no emulator necessary. It's called Spaghetti Kart, you have to provide your own (legally acquired, ya filthy animals) ROM, and it'll run on your desktop like Miyamoto himself put it there. Well, with one or two bugs and the odd crash, maybe. This is still a work-in-progress, technically.