A midfield three of Casemiro, Christian Eriksen and Bruno Fernandes has worked brilliantly for Manchester United this season, but two of those players were unavailable to play Leeds on Wednesday night and the midfield was unbalanced.
Eriksen sustained an ankle injury against Reading in the FA Cup and could be sidelined until May, and Casemiro is serving a three-match suspension after picking up a red card at the weekend.
Donny van de Beek and Scott McTominay are also currently sidelined with different concerns, so United lined up with Fred, Marcel Sabitzer and Bruno Fernandes in midfield against Leeds.