Manchester United will try to move on quickly from their late collapse against Sevilla in midweek, but the absence of their two best defenders will be a lasting reminder of the damage that was done.
United head into next week's second leg in Spain with a strong chance of making it into the final four of the Europa League, though those chances of progression have certainly diminished following their latest injury update.
Raphael Varane will miss a few weeks after he was withdrawn with an injury at half-time of the match. It is the eighth separate illness or injury he has suffered in less than two years at the club, forcing him to miss 25 matches already.
