Manchester United were dumped out of the FA Cup by Middlesbrough on penalties to prolong their near five-year trophy drought.
Anthony Elanga was the only man to miss in a mammoth shoot-out, with a total of 16 spot-kicks being taken.
Cristiano Ronaldo dragged an early penalty wide before Jadon Sancho gave United the lead after 25 minutes, with Ralf Rangnick's side showing they meant business in a competition of great importance to them.