Manchester United players Victor Lindelof and Scott McTominay have both missed out on featuring against Nottingham Forest due to illness.
Both started and played the full 90 minutes during the midweek Carabao Cup fourth round tie against Burnley, with McTominay even assisting Marcus Rashford's second goal of the night. Harry Maguire also missed that match through illness but has recovered sufficiently for a place on the substitute's bench.
With two natural central defenders and another defensive-minded player in McTominay, who has previously played at centre-back on occasion for the club and internationally for Scotland, affected, manager Erik ten Hag has been forced to find a creative replacement. Luke Shaw moves across from left-back to partner Raphael Varane, who featured for France in the World Cup final just nine days ago, at the heart of the Man United defence.