West Ham United travel to Lyon vying for a spot in the Europa League semi-finals, with the tie delicately poised following a 1-1 draw in London last Thursday.
The Hammers have not reached the last-four stage of a major European competition since finishing runner-up in the 1976 European Cup Winners' Cup.
Meanwhile, Lyon 's European pedigree cannot be ignored after they made the semi-finals of the Champions League in the 2019/20 season.
After the controversial first leg in east London last week, which was a hot-tempered affair, more thrills and spills are expected again in France.
Neither side are in sparkling form heading into the second leg, but Lyon's recent results certainly provide more room for optimism than West Ham’s, who have been enduring a topsy-turvy time of late.
Ahead of the game, our tipster Robert Mann takes a look at some of the best bets from Lyon vs West Ham United to get your teeth stuck into.
Lyon vs West Ham United betting tips & predictions
Lyon are 23/20 to win, with West Ham United priced at 21/10 to come away with the victory. A draw is priced at 23/10.
Prediction: Lyon to win 2-0 (10/1)
To win in 90 minutes: Lyon (23/20)
The Hammers have lost five away games on the spin, including the 2-0 defeat at Brentford last time out, while they also suffered a 1-0 loss at the hands of Sevilla in their most recent Europa League away clash.
With that said, it will be difficult to back David Moyes' men and they look set to struggle against a solid Lyon side, who have only lost three times at home from 20 matches in all competitions this season.
First Goalscorer: Karl Toko Ekambi (9/2)
A solid reason behind Lyon’s impressive run in the Europa League has been the form of Cameroon international Karl Toko Ekambi, who is the joint leading scorer in this year's competition with six goals.
As West Ham have failed to keep a clean sheet in their last four outings - conceding seven goals during that period - Toko Ekambi will be relishing the chance to have another go at Moyes' fragile backline.
To have one or more shots on target: Tomas Soucek (11/10)
While Czech Republic international Tomas Soucek may not get on the scoresheet, he should at least get one shot on target in tonight's affair.
Soucek has had five shots on target in this term’s Europa League - only Said Benrahma with seven has achieved more than this for the Hammers - and there is every chance the midfielder will test the goalkeeper's palms again.
Odds are correct at the time of publication and are, as always, subject to change.
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Lyon team news
Lyon's first-choice goalkeeper Anthony Lopes was taken off on the half-hour mark against Strasbourg at the weekend and, as a result, will not feature tonight.
Peter Bosz's midfield dilemma is not helped by Maxence Caqueret's knee injury and a knock for Thiago Mendes, while Lucas Paqueta, Rayan Cherki, Lenny Pintor and Sinaly Diomande are all out of contention as well.
Lyon possible starting lineup:
Pollersbeck; Gusto, Lukeba, Boateng, Emerson; Ndombele, Mendes; Faivre, Reine-Adelaide, Toko Ekambi; Dembele
West Ham United team news
West Ham are currently dealing with a lack of midfield options and Moyes must rethink his defensive options, with Cresswell serving his European suspension and Kurt Zouma suffering an ankle injury in the Brentford loss.
With Zouma confirmed to be missing out, Issa Diop will be on standby, while Angelo Ogbonna continues to recover from knee surgery and Mark Noble will hope to recover from illness in time for Thursday. Manuel Lanzini is also back from a ban served in the first leg.
West Ham United possible starting lineup:
Areola; Johnson, Dawson, Diop, Masuaku; Rice, Soucek; Bowen, Fornals, Benrahma; Antonio
