Gloucester head coach George Skivington has confirmed that Louis Rees-Zammit is a major doubt for Wales' opening match of the Six Nations at least.
The flying wing was injured in Gloucester's defeat at Leicester last week and faces a huge task to be ready to play against Ireland in Cardiff on February 4.
Skivington said after Gloucester's 8-6 defeat of London Irish in the Gallagher Premiership on New Year's Eve: "He is unlikely to need an operation but his ankle is in a boot with the prognosis not forthcoming because we haven't been able to receive the scans this week because of hospital delays.