Liverpool will have to end their Real Madrid hoodoo if they are to take a step nearer a fourth Champions League final in six seasons.
The Reds have been paired with the Spanish side after the draw for the last 16 was completed in Nyon, Switzerland on Monday.
Jurgen Klopp's side, who have reached the knockout stages for the sixth successive time, will host Real in the first leg in February before the away leg three weeks later.