Paul Gorst: The road to St Petersburg resumes at one of football’s iconic venues this evening.
But Liverpool will have little fear or trepidation when they are entertained by Serie A champions Inter.
With a full squad to choose from, Jurgen Klopp can - and should - go as strong as possible for the trip to Italy.
The big question is what to do over that third midfield spot.
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Jordan Henderson, in truth, has not been in great form the last month or two and with Naby Keita perhaps pushing hardest in the rest of the pack, is it time to give the Guinea international a start alongside Thiago Alcantara and Fabinho?
The trio have never started together but it does, on paper at least, offer a nice blend and you feel Keita will be desperate to put right the misery he suffered on his last start in the Champions League knockout stages when he was hauled off before half time at Real Madrid.
The other dilemma centres around the forward options with five vying for three spots. I’m restoring 17-goal Diogo Jota to his central role and taking out Roberto Firmino.
My team (4-3-3): Alisson; Alexander-Arnold, Matip, Van Dijk, Robertson; Fabinho, Keita, Thiago; Salah, Jota, Mane.
Ian Doyle: The Champions League is back. And that means, mercifully, there will be the return of a proper pre-match anthem.
But what is Jurgen Klopp to do against Inter Milan in Italy this evening?
The Liverpool boss certainly has plenty of options given there is a full-strength squad from which to choose.
Worth bearing in mind, though, is there can be five substitutions, and Klopp is likely to make use of them all.
Alisson Becker, Virgil van Dijk, Trent Alexander-Arnold and Andy Robertson comprise four pillars of the defence as usual. But I'd be tempted to bring in Ibrahima Konate in place of Joel Matip at centre-back.
In midfield, Thiago Alcantara returns to join Fabinho. The third spot, though, is a bit more tricky, and I'd like to see Alex Oxlade-Chamberlain in there.
Up top, Diogo Jota can step back in down the centre, with Mohamed Salah right and, yes, Luis Diaz down the left. A little curveball for Inter, methinks.
My team (4-3-3): Alisson; Alexander-Arnold, Konate, Van Dijk, Robertson; Fabinho, Thiago, Oxlade-Chamberlain; Salah, Jota, Diaz.
Joe Rimmer: Liverpool will know they have a very real shot at winning their seventh European Cup this year.
And this the squad Jurgen Klopp has at his disposal, it means he can deploy a really strong team here.
I'd tweak the defence to bring in Ibrahima Konate - no point in pushing Joel Matip too hard with his previous injury record.
And after a poor performance at Burnley, Jordan Henderson can make way for Thiago Alcantara, whose Champions League experience can be a major asset for the Reds in the San Siro.
He lines up alongside scoring sensation Fabinho and Naby Keita, who should be afforded the opportunity to build on a promising display at the weekend.
Up front, I'd mix things up against by giving Luis Diaz another start in place of Sadio Mane.
My team (4-3-3): Alisson; Alexander-Arnold, Konate, Van Dijk, Robertson; Fabinho, Thiago, Keita; Salah, Jota, Diaz.
