Newcastle can still take advantage against Leicester despite the Foxes' good record after trips abroad. We know that Leicester have not shown signs of fatigue when they've played in Europe. They have a massive game against PSV Eindhoven in the Europa Conference League and win, lose or draw I think they will have spent the week focused on the Dutch giants.
Their minds will have been over in Holland and then there is the travel aspect to think about to. I think they will go all out to win against PSV and won't worry too much about Sunday.
In the past rounds that will have been different because you are in a group scenario. And they will have had one eye on their Premier League fixtures with the results showing, not least the 4-0 win against Newcastle just 48 hours after City played against Napoli in Italy.