Mikel Arteta faces the biggest game of his managerial career to date as Arsenal go head-to-head with Manchester City on Wednesday. In what is one of the biggest top-of-the-table clashes in a title race for many a year, it may well be a case of winner takes all.
Pep Guardiola's side have continued to sweep through all those that come before them while the Gunners have started to crumble. That can be overturned with a positive result at the Etihad Stadium but it will have to be done without William Saliba.
The Frenchman is not expected to be fit to face City after The Athletic reported that his back issue is proving to be persistent at exactly the wrong time. Although some hope remains that he will play again this season, it is a major blow.