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LiveScience
LiveScience
Jane Palmer

Ketamine may treat depression by 'flattening the brain's hierarchies,' small study suggests

An illustration of a head composed of nested, colorful outlines in a psychedelic style.

DENVER—A single dose of ketamine may subtly reshape how different regions of the brain communicate, a new study suggests.

The research, presented June 19 at the Psychedelic Science 2025 conference, is one of the first to investigate ketamine’s impact on neuroplasticity — the ability to adapt to experiences by forming new connections and pathways — in the brains of living people. The findings have not been peer-reviewed yet.

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