Keselowski and his RFK Racing Ford team-mate Chris Buescher led a combined 74 of the 212 laps, with Keselowski leading the most with 42, and he won the first stage.
But they lost their stranglehold at the front of the field with four laps remaining, when Richard Childress Racing Chevrolet pairing Kyle Busch and Austin Dillon drafted past their Mustangs, with more Chevys pushing them from behind.
