Keith Earls may have played his last game for Munster after suffering a groin injury in training.
Ireland star Earls, 35, could yet sign a new deal with the Reds that would take him into a 17th season with his native province.
Munster travel to face Glasgow Warriors at Scotstoun on Saturday night but even if Munster make it to the final on May 27 then it is expected the Limerick flyer will not be ready to return.