The fact that a Champions League quarter-final does not represent the biggest game of Liverpool's week tells you all about how high the stakes are at Anfield right now. But while many have already earmarked the Reds as semi-finalists for the third time under Jurgen Klopp, given their 3-1 first-leg lead against Benfica in Lisbon last week, the manager himself is typically not allowing complacency to set in.
"The next game has absolutely no influence on the line-up [tonight], but the last game obviously has," he said in reference of the two matches against Manchester City either side of Wednesday's second leg.
With a healthy advantage established at Estadio da Luz and with an FA Cup semi-final against their great rivals City to come on Saturday, it is easy to see why some would suggest the weekend's trip to Wembley is the most significant.