
Despite starting the 2025 NFL season 3-0, the 49ers are dealing with an abundance of injuries on both sides of the football. Defensive end Nick Bosa tore his ACL last weekend and is out for the season, quarterback Brock Purdy is dealing with turf toe and may not play again this week, and tight end George Kittle has been on injured reserve since Week 1 after straining his hamstring.
On top of all of it, star wide receiver Brandon Aiyuk remains on the PUP list as he recovers from the torn ACL he suffered last season. Unfortunately, as revealed by general manager John Lynch, the pass catcher hasn't had a setback—but isn't close to returning: