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Joe Manniello

Joe Manniello's Week 4 NFL picks

As we approach the quarter-mark of the NFL season, you should start to have a feel for certain teams and matchups. Some will always be hard to figure out (we're looking at you, Chargers), but for the most part, three to four games are a good enough sample size to develop a read ... if there is such a thing in this unpredictable league.

Favorites went 8-8 against the spread (ATS) last week and are now 23-23-1. Home teams went 6-9-1 straight up and 7-9 ATS, bringing their totals to 25-22-1 and 24-23-1.

My three most confident picks are Arizona, the Rams and Buffalo. With the Pittsburgh-Tennessee game postponed, avoid the Minnesota-Houston matchup for obvious reasons.

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