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Joe Manniello

Joe Manniello's Week 3 NFL picks

If I would've told you before the season that there would be two teams favored by 20-plus points in Week 3, you would've said, "Yeah, right. What's next? Ben Roethlisberger, Drew Brees, Sam Darnold and Eli Manning all will be out, too?"

It's been a crazy start to the season, highlighted by QB turnover and hard-to-believe spreads. This is the first week since the 1987 strike season that multiple teams are at least 20-point underdogs, according to ESPN. There's a reason the Dolphins and Jets are getting so many points, so don't think twice and lay the big number.

Underdogs went 9-7 against the spread (ATS) last week and are 19-13 overall.

My most confident picks ATS are the Colts, Cowboys, Patriots and Vikings. Two tricky games to avoid: Panthers-Cardinals and Bears-Redskins.

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