Week 1 is all about the unknown. Week 2 is all about the overreaction. Teams such as the Ravens, Titans and Raiders may not play a more complete game the rest of the season. The Bears, Steelers and Browns likely already played their worst.
Don't put too much stock into one week. There are a couple of overreaction lines, so take advantage. Underdogs went 10-6 against the spread (ATS) in Week 1, with five winning outright. There are eight road favorites, and a bunch of small point spreads, making this one of the more difficult weeks I've seen in a long time.
My most confident picks ATS are the Jaguars, Colts, Bengals and Broncos. Two tricky games to avoid: Browns-Jets and Eagles-Falcons.